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Dr. HUI Lai Ming, Christy 許麗明

BSocSci (Psychology) (HKU), PhD (Psychiatry) (HKU)

Associate Professor, Department of Psychiatry, HKU
Member of Departmental Research Postgraduate Committee, Department of Psychiatry, HKU

Deputy Programme Director of Master of Psychological Medicine (Psychosis Studies), HKU (since 2022)
Vice-Chairperson of Knowledge Development & Transfer of Hong Kong Early Psychosis Foundation (EPISO)
Secretary of Hong Kong Early Psychosis Foundation (EPISO)
Secretary and executive board member of Asian Network of Early Psychosis (ANEP)
Member of Hong Kong Schizophrenia Research Society (SRS)
Member of International Early Psychosis Association (IEPA)

Email: christy@lmhui.com
The HKU Scholars Hub Page address: http://hub.hku.hk/cris/rp/rp01993
Research Gate address: http://www.researchgate.net/profile/Christy_Hui
ORCID: 0000-0001-6912-208X

Biography

Dr. Hui Lai-ming Christy is currently an Associate Professor at the Department of Psychiatry in University of Hong Kong. She has been specialized in psychosis studies with particular interest in relapse prevention, medication adherence, cognitive dysfunction, early intervention and the long-term outcomes of early psychosis. She is also specialized in research in the prevention and early intervention in youth and women’s mental health.

Research Interests and Focus:

  • Relapse prediction in psychosis

    • Neurocognitive markers and its underlying mechanisms

    • Dopaminergic activity and relapse in patients who discontinued medication

  • Decision on early medication discontinuation or maintenance in remitted first episode psychosis, and its long-term clinical and functional outcome

  • Psychiatrists’ views towards medication discontinuation in remitted first episode psychosis

  • Clinical and cognitive correlates of medication non-compliance 

  • Baseline clinical and cognitive differences and short-term outcome between patients with delusional disorder and schizophrenia

  • Semantic dysfunction, network analysis, and its relationship with change in psychopathology

  • Development and evaluation of Early Intervention Service for psychotic disorders in Hong Kong

  • Women’s mental health

  • Youth mental health

Selected Publications

For a complete list of publications, please visit: https://www.researchgate.net/profile/Christy_Hui

*Corresponding author
#Co-first author

Maintenance medication and discontinuation in psychosis 

  • Hui CLM*, Lam BST, Lee EHM, Chan SKW, Chang WC, Suen YN, Chen EYH (2020). Perspective on medication decisions following remission from first-episode psychosis. Schizophrenia Research, 225:82-89.

  • Hui CLM*, William G Honer, Edwin HM Lee, Wing Chung Chang, Sherry KW Chan, Eric YH Chen (2019). Factors associated with successful medication discontinuation after a randomized clinical trial of relapse prevention in first-episode psychosis: A 10-Year Follow-up. JAMA Psychiatry, 76(2): 217-219.

  • Hui CLM*, William G Honer, Edwin HM Lee, Wing Chung Chang, Sherry KW Chan, Emily SM Chen, Edwin PF Pang, Simon SY Lui, Dicky WS Chung, Wai Song Yeung, Roger MK Ng, William TL Lo, Peter B Jones, Pak Sham, Eric YH Chen (2018). Long-term effects of discontinuation from antipsychotic maintenance following first episode schizophrenia and related disorders. Lancet Psychiatry, 5:432-442.

  • Hui CLM*, Eric YH Chen (2014). Early medication discontinuation on long-term recovery outcome in first-episode psychosis. JAMA Psychiatry, 71(2):207-208.

  • Hui CLM*, GHY Wong, JYM Tang, WC Chang, SKW Chan, EHM Lee, MML Lam, CPY Chiu, CW Law, DWS Chung, Steve Tso, EPF Pang, KT Chan, YC Wong, FYM Mo, KPM Chan, SF Hung, William G Honer, Eric YH Chen (2013). Predicting 1-year risk for relapse in patients who have discontinued or continued quetiapine after remission from first-episode psychosis. Schizophrenia Research, 150(1):297-302.

  • Eric YH Chen, Hui CLM, May ML Lam, Cindy PY Chiu, CW Law, Dicky WS Chung, Steve Tso, Edwin PF Pang, KT Chan, YC Wong, Flora YM Mo, Kathy PM Chan, TJ Yao, SF Hung, William G Honer (2010). Maintenance therapy in patients with remitted first-episode psychosis following one year of treatment: a randomised controlled study comparing discontinuation versus quetiapine. British Medical Journal, 341:c4024

Neurocognitive predictors of relapse in psychosis

  • Tao TJ#, Hui CLM#*, Hui PWM, Ho ECN, Lam BST, Wong AKH, See SHW, Chan EWT, Suen YN, Lee HML, Chan SKW, Chang WC, Lo WTL, Chong CSY, Siu CMW, Choi YY, Pomarol-Clotet E, McKenna PJ, Honer WG, Chen EYH (2022). Working memory deterioration as an early warning sign for relapse in remitted psychosis: A one-year naturalistic follow-up study. Psychiatry Research (in press) https://doi.org/10.1016/j.psychres.2022.114976  

  • Tao TJ, Hui CLM*, Lam BST, Ho ECN, Hui PWM, Suen YN, Lin JJ, Tong ACY, Lee EHM, Chan SKW, Chang WC, Chen EYH (2021). Mindfulness meditation for Chinese patients with psychosis: A systematic review and meta-analysis. Schizophrenia Research, 237:103-114.

  • Hui CLM*, Lam BST, Wong AKH, Tao TJ, Ho ECN, Suen YN, Lee EHM, Chan SKW, Chang WC, Chong CSY, Siu CMW, Lo WTL, Chen EYH (2021). ReMind, a smartphone application for psychotic relapse prediction: A longitudinal study protocol. Early Intervention in Psychiatry, 15(6):1659-1666.

  • Hui CLM*, William G Honer, Edwin HM Lee, Wing Chung Chang, Sherry KW Chan, Emily SM Chen, Edwin PF Pang, Simon SY Lui, Dicky WS Chung, Wai Song Yeung, Roger MK Ng, William TL Lo, Peter B Jones, Pak Sham, Eric YH Chen (2018). Predicting first-episode psychosis patients who will never relapse after 10 years. Psychological Medicine, 49(13):2206-2214.    

  • Hui CLM*, Li YK, Li AWY, Lee EHM, Chang WC, Chan SKW, Lam SY, Thornton AE, Sham P, Honer WG, Chen EYH (2016). Visual working memory deterioration preceding relapse in psychosis. Psychological Medicine, 46(11):2435-2444. 

  • Hui CLM, Cindy PY Chiu, YK Li, CW Law, WC Chang, Sherry KW Chan, Edwin HM Lee, Pak Sham, Eric YH Chen (2015). The effect of paternal age on relapse in first-episode schizophrenia. The Canadian Journal of Psychiatry, 60(8):346-353.

  • Hui CLM*, Julia Longenecker, GHY Wong, JYM Tang, WC Chang, SKW Chan, EHM Lee, ELW Dunn, MYK Miao, WS Yeung, CK Wong, WF Chan, WN Tang, Eric YH Chen (2012). Longitudinal changes in semantic categorization performance after symptomatic remission from first-episode psychosis: a 3-year follow-up study. Schizophrenia Research, 137(1-3):118-123.

Compliance to antipsychotics treatment in psychosis

  • Hui CLM, Poon VWY, Ko WT, Miao HY, Chang WC, Lee EHM, Chan SKW, Lin J, Chen EYH (2016). Risk factors for antipsychotic medication non-adherence behaviors and attitudes in adult-onset psychosis. Schizophrenia Research, 174:144-149.

  • Hui CLM, Poon WY Venessa, Kwok SK Vivian, Chang WC, Chan KW Sherry, Lee HM Edwin, Chen YH Eric (2015). Prevalence and predictors of medication non-adherence among Chinese patients with first-episode psychosis. Psychiatry Research, 228(3):680-687.

  • Hui CLM, Eric YH Chen, CS Kan, KC Yip, CW Law, Cindy PY Chiu (2006). Detection of non-adherent behavior in early psychosis. Australian and New Zealand Journal of Psychiatry, 40:446-451.

Early intervention for psychotic disorders

  • Hui CLM, Wong AKH, Ho ECN, Lam BST, Hui PWM, Tao TJ, … Chen EYH* (2022). Effectiveness and optimal duration of early intervention treatment in adult-onset psychosis: A randomized clinical trial. Psychological Medicine, 11:1-13.

  • Hui CLM*, WC Chang, SKW Chan, EHM Lee, WWY Tam, DC Lai, GHY Wong, JYM Tang, FWS Li, KF Leung, Sarah M McGhee, PC Sham, Eric YH Chen (2014). Early intervention and evaluation for adult-onset psychosis: The JCEP study rationale and design. Early Intervention in Psychiatry, 8(3):261-268.

  • Hui CLM*, Adrienne WY Li, CM Leung, WC Chang, Sherry KW Chan, Edwin HM Lee, Eric YH Chen (2014). Comparing illness presentation, treatment and functioning between patients with adolescent- and adult-onset psychosis. Psychiatry Research, 220(3):797-802.

  • Hui CLM, Jennifer YM Tang, Gloria HY Wong, WC Chang, Sherry KW Chan, Edwin HM Lee, Eric YH Chen (2013). Predictors of help seeking duration in adult onset psychosis in Hong Kong. Social Psychiatry and Psychiatric Epidemiology, 48(11):1819-1828.

  • Hui CLM, Carmen Morcillo, Debra A Russo, Jan Stochl, Gillian F Shelley, Michelle Painter, Peter B Jones, Jesus Perez* (2013). Psychiatric morbidity, functioning and quality of life in young people at clinical high risk for psychosis. Schizophrenia Research,148,175-180.

Delusional disorders and schizophrenia

  • Hui CLM, Lee EHM*, Chang WC, Chan SKW, Chen EYH (2016). Comparing delusional disorder and schizophrenia – a reply. Psychological Medicine, 46(7):1561-1562.

  • Hui CLM, Lee EHM*, Chang WC, Chan SKW, Lin J, JQ Xu, Chen EYH (2015). Delusional disorder and schizophrenia: a comparison of the neurocognitive and clinical characteristics in first-episode patients. Psychological Medicine, 45(15):3085-3095.

Youth mental health

  • Hui CLM, Wong SM, Yu TY, Lau TT, Choi O, Tsang S, Suen YN, Lam BY, Wong CS, Lui SS, Chan KT, Wong MT, Wong GH, Chan SK, Lee EH, Chang WC, Wilkins A, Chen EY* (2022). Visual-stress-related cortical excitability as a prospective marker for symptoms of depression and anxiety in young people. European Archives of Psychiatry and Clinical Neuroscience. doi: 10.1007/s00406-022-01469-7. Epub ahead of print. PMID: 35972556.

  • Hui CLM, Suen YN, Lam BYH, Wong SMY, Wong CSM, Lui SSY, Chan KT, Wong MTH, Chan SKW, Lee EHM, Chang WC, Wong GHY, Chen EYH* (2022). LevelMind@JC: Development and evaluation of a community early intervention program for young people in Hong Kong. Early Intervention in Psychiatry, 16(8):920-925.

Book Chapters

  • Christy LM Hui (2022). Psychosocial Transition. In Youth Mental Health A Primer, edited by Eric YH Chen and Michael TH Wong, pp. 30-35. Infolink Publishing Limited. 

  • Christy LM Hui (2022). Insomnia and Other Sleep Problems. In Youth Mental Health A Primer, edited by Eric YH Chen and Michael TH Wong, pp. 133-142. Infolink Publishing Limited. 

  • Christy LM Hui, W.C. Chang, Sherry K.W. Chan, Edwin H.M. Lee, Y.N. Suen, Eric Y.H. Chen (2020). International Services for Assessing and Treating Psychosis Risk. In Risk Factors for Psychosis, edited by Andrew D. Thompson and Matthew R. Broome, pp. 383-398. Academic Press.

  • 陳友凱, 陳喆燁, 張頴宗, 李浩銘, 許麗明 (2014).《思覺失調個案剖析》中華書局(香港)有限公司.

  • Christy LM Hui (2013). Medication adherence: specific issues in early psychosis in Asia. In Early psychosis intervention A culturally adaptive clinical guide. (Ed. Eric YH Chen, Helen Lee, Gloria HK Chan and Gloria HY Wong), pp. 273-279. Hong Kong University Press.

  • Christy LM Hui (2013). Relapse intervention and related issues. In Early psychosis intervention A culturally adaptive clinical guide. (Ed. Eric YH Chen, Helen Lee, Gloria HK Chan and Gloria HY Wong), pp. 283-289. Hong Kong University Press.

Grants

In the capacity of PI:

  • Hong Kong Jockey Club Charities Trust 2019: “Community-based Youth Mental Wellness Hub (LevelMind@JC)”.

  • Hong Kong Jockey Club Charities Trust 2021. “Jockey Club Mental Wellness Project for Women”.

  • National Institutes of Health 2020. “Trajectories and Predictors in the Clinical High Risk for Psychosis Population: Prediction Scientific Global Consortium”.

  • Health and Medical Research Fund (HMRF) 2019/20: "Long-term clinical and functional outcome of adult-onset patients with delusional disorder and schizophrenia: a 10-year follow-up study".

Awards/Fellowship/Recognition:

  • In the year of 2019, 2020, 2021 and 2022, according to Clarivate Analytics, Dr. Hui is among the top 1% worldwide by citations in at least one of the 22 research fields. (Refer to: http://hub.hku.hk/local/top1pc/top1pc.jsp)

  • Faculty Outstanding Research Output Award 2019 – paper published in Lancet Psychiatry as first and corresponding author.

  • Faculty Award for Outstanding Research Postgraduate Student – as the primary supervisor for Miss Ko Wai Tung’s MPhil during the period of 2016-2018.

  • Young Scientist Travel Award, 9th Annual Meeting of Japanese Society of Schizophrenia Research, Kyoto, Japan 2014.

  • Doris Zimmern HKU-Cambridge Hughes Hall Fellowships 2012

  • Young Scientist Award, 14th Biennial Winter Workshop on Schizophrenia Research, Montreux, Switzerland 2008.

  • Young Scientist Award, 13th Biennial Winter Workshop on Schizophrenia Research, Davos, Switzerland 2006.

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