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Dr. Cheng Pak Wing, Calvin 鄭柏榮

MBBS (HKU), FHKAM(Psychiatry), FHKCPsych
MA in Philosophy (CUHK)
Master of Buddhist Studies (HKU)

Clinical Assistant Professor

Director of Knowledge Exchange
Honorary Associate Consultant, Queen Mary Hospital
Associate Editor-in-chief, East Asian Archives of Psychiatry
Representative of Hong Kong West Cluster, Clinical Division of Old Age Psychiatry, The Hong Kong College of Psychiatrists

Member of HKSAR Mental Health Review Tribunal

Email: chengpsy@hku.hk
The HKU Scholars Hub Page address:https://hub.hku.hk/cris/rp/rp02337

Biography:

Dr. Calvin Cheng joined the department in November 2017 as a clinical assistant professor. He is also the honorary associate consultant of psychogeriatric services in the Hong Kong West Cluster. Before joining the department, he obtained Fellowship of the Hong Kong College of Psychiatrists in 2014. He was the visiting fellow and trained as a functional MRI specialist under Athinoula A. Martinos Center for Biomedical Imaging in the Massachusetts General Hospital in same year. He also attended intensive courses of transcranial magnetic and electrical stimulation in Harvard Medical School, Universitätsmedizin Göttingen and University Medical Center Utrecht from 2014 to 2016. His current research interests reside in pharmacological and non-pharmacological interventions for geriatric depression, structural and functional brain mapping, non-invasive transcranial brain stimulation for mood disorder and cognitive impairment in elderly. He obtained Distinguished Young Fellow Award given by the Hong Kong Academy of Medicine in 2018.

Research Interests

  • Non-invasive brain stimulation (NIBS) i.e. Repetitive Transcranial magnetic stimulation (rTMS), Direct current stimulation (tDCS) and Transcranial pulse stimulation (TPS)

  • Old age psychiatry and neurocognitive disorder (dementia)

  • Neuroimaging

  • Depression and related issues

  • Service/intervention evaluation

Current research projects

  • Efficacy of a 24-week long term transcranial pulse stimulation (TPS) on cognition and brain structure in older adults with mild neurocognitive disorder (NCD) (HMRF – Full grant, 201801159009, PI)

  • High-definition transcranial direct current stimulation (HD-tDCS) as augmentation therapy in late-life depression (LLD) with suboptimal response to treatment - double-blinded randomized sham-controlled trial (HMRF, 17181141, PI)

  • Inflammation hypothesis for late-life depression (LLD): How the brain connectivity mediates the effect of inflammation on LLD symptoms

  • Parent Education in Mental Health – Primary School (PEMH) – Service evaluation project

Selected Publication List

Non-invasive brain stimulation

  • Ngan, S. T. J., Chan, L. K., Chan, W. C., Lam, L., Li, W. K., Lim, K., ... & Wing, C. P.* (2022). High-Definition Transcranial Direct Current Stimulation (HD-tDCS) as Augmentation Therapy in Late-Life Depression (LLD) with Suboptimal Response to Treatment–a Study Protocol for a Double-Blinded Randomized Sham-Controlled Trial.

  • Cheng, P. W. C.*, & Fong, K. H. T. (2021). Efficacy and safety of transcranial pulse stimulation (TPS) in older adults with mild neurocognitive disorder–an open-label trial. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 14(6), 1636.

  • Cheng, P. W. C.*, Louie, L. L. C., Wong, Y. L., Wong, S. M. C., Leung, W. Y., Nitsche, M. A., & Chan, W. C. (2020). The effects of transcranial direct current stimulation (tDCS) on clinical symptoms in schizophrenia: A systematic review and meta-analysis. Asian Journal of Psychiatry, 53, 102392.

  • Cheng, C. P.* (2020). New 21st Century Intervention in Psychiatry – Non-invasive Brain Stimulation (NIBS): Potential and Future Development. The Hong Kong Medical Diary, 25(3), 12-14.

  • Wong, H. L., Chan, W. C., Wong, Y. L., Wong, S. N., Yung, H. Y., Wong, S. M. C., & Cheng, P. W. C.* (2019). High‐definition transcranial direct current stimulation—An open‐label pilot intervention in alleviating depressive symptoms and cognitive deficits in late‐life depression. CNS neuroscience & therapeutics, 25(11), 1244-1253. 

  • Cheng, C. P. W.*, Wong, C. S. M., Lee, K. K., Chan, A. P. K., Yeung, J. W. F., & Chan, W. C. (2018). Effects of repetitive transcranial magnetic stimulation on improvement of cognition in elderly patients with cognitive impairment: a systematic review and meta‐analysis. International journal of geriatric psychiatry, 33(1), e1-e13.  

  • Cheng, C. P.*, Chan, S. S., Mak, A. D., Chan, W. C., Cheng, S. T., Shi, L., ... & Lam, L. C. W. (2015). Would transcranial direct current stimulation (tDCS) enhance the effects of working memory training in older adults with mild neurocognitive disorder due to Alzheimer’s disease: study protocol for a randomized controlled trial. Trials, 16(1), 479.

  • Cheung, T., Lam, J. Y. T., Fong, K. H., Cheng, C. P. W., Ho, A., Sittlington, J., ... & Li, T. M. H. (2023). Evaluating the Efficacy of Electrical Vestibular Stimulation (VeNS) on Insomnia Adults: Study Protocol of a Double-Blinded, Randomized, Sham-Controlled Trial. International Journal of Environmental Research and Public Health, 20(4), 3577.

  • Cheung, T., Ho, Y. S., Fong, K. H., Lam, Y. T. J., Li, M. H., Tse, A. C. Y., ... Calvin, PW Cheng & Beisteiner, R. (2022). Evaluating the Safety and Efficacy of Transcranial Pulse Stimulation on Autism Spectrum Disorder: A Double-Blinded, Randomized, Sham-Controlled Trial Protocol. International Journal of Environmental Research and Public Health, 19(23), 15614.

  • Cheung T, HO YS, Yeung WF, Leung SF, Fong K, Fong KH, Kranz GS, Beisteiner R, Cheng C. Effects of transcranial pulse stimulation (TPS) on young adults with symptoms of depression–a Pilot Randomized Controlled Trial. Frontiers in Neurology.:515. of depression – a pilot randomized control trial. (2022) Frontiers in Neurology

  • Lo, Ka Ying Heidi, Helene Janine Hopman, Sheung Chun Chan, Wai Ho Steven Chau, Pak Wing Calvin Cheng, Kam Yee Cheung, Hiu Ha Debby Lam. (2022). Concurrent anodal transcranial direct current stimulation (tDCS) with cognitive training to improve cognition in schizophrenia. Schizophrenia research 241 (2022): 184-186.

  • Hanna Lu, Sandra Sau Man Chan, Wai Chi Chan, Cuichan Lin, Calvin Pak Wing Cheng & Lam Linda Chiu Wa (2019). Randomised Controlled Trial of TDCS on Cognition in 201 Seniors with Mild Neurocognitive Disorder. Annals of Clinical and Translational Neurology. DOI:10.1002/acn3.50823

Old age psychiatry and dementia

  • Fong, T. K. H., Cheung, T., Chan, W. C., & Cheng, C. P. W.* (2022). Depression, Anxiety and Stress on Caregivers of Persons with Dementia (CGPWD) in Hong Kong amid COVID-19 Pandemic. International Journal of Environmental Research and Public Health, 19(1), 184.

  • YL Wong, CPW Cheng*, CSM Wong, SN Wong, HL Wong, S Tse, GHY Wong, WC Chan. (2021). Cognitive Stimulation for Persons with Dementia: a Systematic Review and Meta- Analysis. East Asian Arch Psychiatry, 31:55-66.

  • Louie Larissa Lok Chi., Chan Wai Chi., & Cheng Pak Wing, Calvin*. (2021). Suicidal risk in elderly patients with depression during Coronavirus Disease 2019 epidemic: A Case Control Study. East Asian archives of psychiatry, 31(1), 3-8.

  • Cheng, C. P. *(2018). Elderly care as one of the important government policy agenda. Hong Kong Med J, 24, 442-3. 

  • Cheng, C. P. W.*, Chiu-Wa Lam, L., & Cheng, S. T. (2016). The Effects of Integrated Attention Training for Older Chinese Adults With Subjective Cognitive Complaints: A Randomized Controlled Study. Journal of Applied Gerontology, 0733464816684622.

  • Yu P.H., Chin C.Y.E., YU J., Fong D.Y.T., Cheng P.W.C., Hu X., Wei and G.X., Siu M.F.P., Tai Chi versus conventional exercise for improving cognitive function in older adults: a pilot randomized controlled trial, Scientific Reports. 2022, 12. http://dx.doi.org/10.1038/s41598-022-12526-5

  • Yu, D. J., Yu, A. P., Leung, C. K., Chin, E. C., Fong, D. Y., Cheng, C. P., ... & Siu, P. M. (2022). Comparison of moderate and vigorous walking exercise on reducing depression in middle-aged and older adults: A pilot randomized controlled trial. European Journal of Sport Science, 1-23. http://dx.doi.org/10.1080/17461391.2022.2079424

  • Recchia, F., Leung, C. K., Chin, E. C., Fong, D. Y., Montero, D., Cheng, C. P., ... & Siu, P. M. (2022). Comparative effectiveness of exercise, antidepressants and their combination in treating non-severe depression: a systematic review and network meta-analysis of randomised controlled trials. British Journal of Sports Medicine, 56(23), 1375-1380.

  • Chin, E. C., Yu, A. P., Leung, C. K., Bernal, J. D., Au, W. W., Fong, D. Y., ... & Siu, P. M. (2022). Effects of exercise frequency and intensity on reducing depressive symptoms in older adults with insomnia: A pilot randomized controlled trial. Frontiers in Physiology, 468.

  • Lu H, Ni X, Chan SS, Chan WC, Cheng CP, Lam LC. Transferability and sustainability of transcranial direct current stimulation on sleep quality and cognition in mild neurocognitive disorder due to Alzheimer’s disease. In2021 Alzheimer's Association International Conference 2021 Jul 26. ALZ.

  • Lam, L.C.W., Lee, A.T., Cheng, S.T., Yip, B.H., Chan, W.C., Fung, A.W., Ma, S.L., Cheng, C.P., Kong, R., Chiu, H.T. and Lai, F.H., (2021). Mindful awareness is associated with a lower risk of anxiety and depressive symptoms in older adults with neurocognitive disorders. Frontiers in Psychiatry, p.1765.

  • VWY Shih, WC Chan, OK Tai, HL Wong, CPW Cheng, CSM Wong. (2021). Mindfulness-Based Cognitive therapy for late-life depression: A Randomized controlled trial. East Asian Archives of Psychiatry, 31(2), 27-35.

Neuroimaging

  • Cheng, P. W. C.*, Chang, W. C., Lo, G. G., Chan, K. W. S., Lee, H. M. E., Hui, L. M. C., ... & Mak, K. F. H. (2020). The role of dopamine dysregulation and evidence for the transdiagnostic nature of elevated dopamine synthesis in psychosis: a positron emission tomography (PET) study comparing schizophrenia, delusional disorder, and other psychotic disorders. Neuropsychopharmacology, 0:1–7; https://doi.org/10.1038/s41386-020-0740-x

  • Cheng, C. P. W.*, Cheng, S. T., Tam, C. W. C., Chan, W. C., Chu, W. C. W., & Lam, L. C. W. (2018). Relationship between Cortical Thickness and Neuropsychological Performance in Normal Older Adults and Those with Mild Cognitive Impairment. Aging and Disease, 9(6), 1020.

  • Wong SM, Suen YN, Wong CW, Chan SK, Hui CL, Chang WC, Lee EH, Cheng CP, Ho GC, Lo GG, Leung EY. Striatal dopamine synthesis capacity and its association with negative symptoms upon resolution of positive symptoms in first-episode schizophrenia and delusional disorder. Psychopharmacology. 2022 Feb 25:1-9.

Depression and related issues

  • Cheung, T., Cheng, C. P. W., Fong, T. K. H., Sharew, N. T., Anders, R. L., Xiang, Y. T., & Lam, S. C. (2022). Immediate psychological impact on healthcare workers, general population and affected individuals of SARS and COVID-19: A systematic review and meta-analysis.

  • Recchia, F., Leung, C. K., Chin, E. C., Fong, D. Y., Montero, D., Cheng, C. P., ... & Siu, P. M. (2022). Comparative effectiveness of exercise, antidepressants and their combination in treating non-severe depression: a systematic review and network meta-analysis of randomised controlled trials. British Journal of Sports Medicine, 56(23), 1375-1380.

  • Ngan, Sze Ting Joanna, and Pak Wing Cheng* (2022) Classification of mindfulness meditation and its impact on neural measures in the clinical population. Frontiers in Psychology: 2471.

  • Kwan KY, Chan LW, Cheng PW, Leung GK, Lau CS. Burnout and well-being in young doctors in Hong Kong: a territory-wide cross-sectional survey. Hong Kong Medical Journal. 2021 Oct 1;27(5):330.

  • Bai, Wei, Yanjie Zhao, Fengrong An, Qinge Zhang, Sha Sha, Teris Cheung, Calvin Pak-Wing Cheng, Chee H. Ng, and Yu-Tao Xiang. "Network Analysis of Insomnia in Chinese Mental Health Professionals During the COVID-19 Pandemic: A Cross-Sectional Study." Nature and Science of Sleep 13 (2021): 1921-1930.

Children mental Health

  • Leung, M. H. B., Ngan, S. T. J., Cheng, P. W. C.*, Chan, F. C. G., CHANG, W. C., Cheung, H. K., ... & Chan, K. L. P. (2023) Sleep Problems in Children with Autism Spectrum Disorder in Hong Kong: A Cross-sectional Study. Frontiers in Psychiatry, 14, 548.

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