Treatment-resistant schizophrenia (TRS) is characterized by persistent psychotic symptoms that fail to respond adequately to first-line antipsychotic medications. Neurodevelopmental deviance has been suggested as a possible aetiology of TRS. However, previous studies examining abnormal neurodevelopmental processes in predicting the development of treatment-resistant schizophrenia have been inconclusive. This talk will share the results of the genetic association between TRS and general cognitive function and some novel genetic loci associated with treatment resistance in schizophrenia after leveraging the genetic overlap between the cognitive traits and TRS.